Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  11
• Reference
  J:24223 Blackburn CC, et al., A high-resolution map of the chromosomal region surrounding the nude gene. Genomics. 1995 Mar 20;26(2):308-17
• ID
  MGI:44923

Genes

Gene	Allele	Assay Type	Description
D11Nds1		PCR amplified length variant	T31
Foxn1	Foxn1^nu	visible phenotype
D11Mit34		PCR amplified length variant	A1113
Evi2a		Southern analysis	p597.1
D11Mit8		PCR amplified length variant	M212

Notes

• Reference
  Authors use Atpb-2, Tca-3, Mip-1a, Mip-1b and Akv4 for Atp1b2, Scya1, Scya3, Scya4 and Emv14 respectively.
• Experiment
  nu/+ progeny derived from BALB/c.nu/+ x BALB/c.nu/nu and CBA.nu/+ x CBA.nu/nu backcrosses were analyzed to determine the proximal and distal boundaries of the Foxn1 locus. The nu/+ progeny were tested initally for the loss of heterozygosity at the D11Nds1 and D11Mit8 loci. Only the BALB/c cross was analyzed for D11Mit8. There were 170 mice tested for nu with D11Nds1 and 381 mice tested for nu with D11Mit8. 34 recombinant nu/+ mice within this region were further tested for D11Mit34 and Evi2. Based on thereported data the authors suggest an order of D11Nds1 - Foxn1 - D11Mit34 - Evi2 - D11Mit8 with a distance of 0.26 +/- 0.26 cMs estimated between D11Mit34 and D11Mit8. Analysis of 505 mice from the CBA.nu/+ x CBA.nu/nu backcross provided the following: D11Nds1 -1.4 +/- 0.50 cM - Foxn1 - 0.2 +/- 0.2 cM - D11Mit34.