Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  4
• Reference
  J:24933 Nolan PM, et al., Heterozygosity mapping of partially congenic lines: mapping of a semidominant neurological mutation, Wheels (Whl), on mouse chromosome 4. Genetics. 1995 May;140(1):245-54
• ID
  MGI:45137

Genes

Gene	Assay Type
D4Mit149	PCR amplified length variant
D4Mit181	PCR amplified length variant
Whl	visible phenotype
D4Mit1	PCR amplified length variant
D4Mit105	PCR amplified length variant
D4Mit97	PCR amplified length variant

Notes

• Experiment
  Wheels (symbol Whl) is a ENU induced semidominant behavioral mutant on a BALB/c background. A locus for Whl was mapped to mouse Chromosome 4 by taking advantage of a partially congenic line derived by outcrossing the heterozygous founder mouse to C57BL/6J for 2 generations. The 13 affected G3 mice were then tested for heterozygosity of BALB/c and C57BL/6J alleles at 68 PCR based markers. A significant association of the mutant phenotype with Chromosome 4 subcentromeric markers D4Mt149, D4Mit181, D4Mit1, D4Mit105 and D4Mit97 was indicated.