Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  16
• Reference
  J:25722 Wardell BB, et al., Aod1, the immunoregulatory locus controlling abrogation of tolerance in neonatal thymectomy-induced autoimmune ovarian dysgenesis, maps to mouse chromosome 16. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4758-62
• ID
  MGI:45138

Genes

Gene	Assay Type	Description
D16Mit58	PCR amplified length variant	MPC713
Aod1	resistance/susceptibility
D16Mit60	PCR amplified length variant	MMH226

Notes

• Experiment
  D3Tx, A/J and (D3Tx x A/J)F1 mice are susceptible to AOD (autoimmunne ovarian dysgenesis disease) whereas C57BL/6J mice are resistant thus allowing for the potenial to genetically map the disease within these strains. One hundred and forty-four D3Tx x (C57BL/6J x A/J)F1 x C57BL/6J backcross mice were generated. Based on chi square analysis significant linkage of AOD (gene symbol Aod1) with Chromsome 16 markers D16Mit58 (p = 0.00086) and D16Mit60 (p = 0.00086) was indicated. AOD is distinguished by 2 phenotypes, presence of anti-ovarian antibodies and oophoritis, which when analyzed independently also segregated with markers on Chromsome 16.