Mapping Data

Experiment

• Experiment
  CROSS
• Chromosome
  8
• Reference
  J:24436 Naggert JK, et al., Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat Genet. 1995 Jun;10(2):135-42
• ID
  MGI:45143

Genes

Gene	Allele	Assay Type	Description
D8Mit246		PCR amplified length variant	MT2796
D8Mit69		PCR amplified length variant	MPC1004
Cpe	Cpe^fat	direct sequencing	Cpe genomic1 and visible
D8Mit131		PCR amplified length variant	MT661
D8Mit29		PCR amplified length variant	A696
Atp6v1b1		PCR amplified length variant	F8, R10
D8Mit73		PCR amplified length variant	MPC351
D8Mit78		PCR amplified length variant	MPC427
D8Mit50		PCR amplified length variant	B730

Notes

• Reference
  Authors present evidence that the fat phenotype is encoded at the Cpe locus on Chromsome 8.
• Experiment
  The fat locus arose on an HRS/J background and was backcrossed onto a C57BLKS/J strain, hence a congenic segment of Chromosome 8 in the region of fat is carried by C57BLKS/J-fat/+. The mice reported here are a sample of 42 from a total of 1,400 intercross progeny. These 42 mice exhibited recombination between D8Mit69 and D8Mit50. Typings here include only fat homozygous mice (HRS/J homozygous).

CROSS

• Type
  Intercross
• Female Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b>/<h> <h> <h> <h> <h> <h> <h> <h> <h>
• Strain
  C57BLKS/J-Cpe
• Male Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b>/<h> <h> <h> <h> <h> <h> <h> <h> <h>
• Strain
  C57BLKS/J-Cpe
• Allele 1
  b from C57BLKS/J
• Allele 2
  h from HRS/J

CROSS Data

MC #mice	D8Mit246	D8Mit69	Cpe	D8Mit131	D8Mit29	Atp6v1b1	D8Mit73	D8Mit78	D8Mit50
1	h	h	h	h	h	h	h	h	h
3	h	b	h	h	h	h	h	h	h
1	h	b	h	h	h	h	h	h	b
17	b	b	h	h	h	h	h	h	h
6	h	h	h	h	h	h	h	b	b
1	b	b	h	h	h	h	h	h	b
1	b	b	h	h	h	h	h	h	h
1	h	h	h	h	h	h	h	b	b
1	b	b	h	h	h	h	h	h	h
1	b	b	h	h	h	h	h	h	b
1	b	b	h	h	h	h	h	b	b
1	h	h	h	h	b	b	b	b	b
1	h	h	h	h	b	h	b	b	b
1	h	h	h	b	b	b	b	b	b
1	h	b	h	h	b	b	h	b	b
3	h	h	h	b	b	b	b	b	b
1	b	b	h	b	b	b	b	b	b