Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  4
• Reference
  J:19245 Morahan G, et al., Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5898-902
• ID
  MGI:45296

Genes

Gene	Assay Type	Description
D4Mit13	PCR amplified length variant	M169
Slc9a1	other	Na<+>/H<+> exchange
Idd11	resistance/susceptibility
D4Mit72	PCR amplified length variant	MPC1053

Notes

• Experiment
  A diabetes susceptibility gene (Idd11) was indicated as mapping to distal Chromosome 4 in 30 nondiabetic homozygous H2^g7 backcross female mice derived from a NOD/Lt x (C57BL/6J x NOD/Lt)F1 mating. Idd11 most likely resides between D4Mit13 and D4Mit72. Authors also analyzed an incipient NOD/Nhe-1 congenic line and suggest that Chromosome 4 gene Slc9a1 may be a candidate for Idd11. The previous symbol for Slc9a1 was Nhe1.