Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  17
• Reference
  J:6009 Whitmore AC, et al., Genetic control of susceptibility of mice to Rous sarcoma virus tumorigenesis. II. Segregation analysis of strain A.SW-associated resistance to primary tumor induction. J Immunol. 1978 Jul;121(1):213-20
• ID
  MGI:45322

Genes

Gene	Assay Type
H2	immunological
Rrsv	resistance/susceptibility

Notes

• Experiment
  The inheritance of susceptibility to Rous tumorigenesis was analyzed in crosses derived between the resistant strain A.SW and susceptible strains A/WySnJ, B10.A, CBA/J and C57BL/10. A locus named Rrsv (resistance to Rous sarcoma) showed association with the H2 locus on mouse Chromosome 17 in mapping analysis using (A/WySnJ x A.SW-H2^s)F2, (A.SW-H2^s x B10.A-H2^a)F2, and (A.SW-H2^s x CBA/J)F2 intercrosses. The results of these crosses indicate that Rrsv may be linked to the K end of the H2 complex. F2 animals homozygous for H2^s alleles exhibit resistance to tumors induced by Rous sarcoma virus whereas F2 animals homozygous for H2^a or H2^k alleles exhibit tumor susceptibility. (Parental strain CBA/J carries the H2^k allele.)