Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:26873 Fijneman RJ, et al., A gene for susceptibility to small intestinal cancer, ssic1, maps to the distal part of mouse chromosome 4. Cancer Res. 1995 Jul 15;55(14):3179-82
• ID
  MGI:45367

Genes

Gene	Assay Type	Description
D4Mit158	PCR amplified length variant	MT1033
Ssic1	resistance/susceptibility

Notes

• Experiment
  Two mouse strains with identical H2 haplotypes were used to identify a gene for susceptibility to small intestinal cancer on mouse Chromosome 4. 67 N3 tumor bearing mice from a (B10.O20 x O20/A)F1 x B10.O20 N3 cross were genotyped using 86 SSLP markers. Susceptibility is conferred by homozygosity of a gene from strain B10.O20. The highest chi-square value was obtained for D4Mit158 (67 cM) a locus for which only 3 of the 67 tumor bearing mice were heterozygous. D4Mit158 is located on distal Chromosome 4. Authors use symbol Ssic1 to represent the locus for susceptibility to small intestinal cancer.