Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  4
• Reference
  J:26686 Miyasaka K, et al., Frequent loss of heterozygosity on chromosome 4 in diethylnitrosamine-induced C3H/MSM mouse hepatocellular carcinomas in culture. Mol Carcinog. 1995 May;13(1):37-43
• ID
  MGI:45505

Genes

Gene	Assay Type	Description
D4Wsm1	PCR amplified length variant
D4Mit9	PCR amplified length variant	M241
D4Mit15	PCR amplified length variant	A122
D4Mit28	PCR amplified length variant	A799
D4Mit46	PCR amplified length variant	Plex90

Notes

• Experiment
  The authors used microsatellite markers to assess loss of heterozygocity (LOH) in hepatocellular carcinoma derived cell lines. The frequency of LOH on Chromsome 4 was extremely high especially in the region distal to D4Wsm1, commonly including D4Mit9, D4Mit15, D4Mit28 and D4Mit46. Because no liver tumor-susceptibility locus has been assigned to Chromosome 4 in previous linkage experiments, the authors assert that interferon alpha or beta, both cell-cycle-regulating genes, mapping to this region may be responsible for hepatocarcinogenesis.