Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  11
• Reference
  J:21194 Nehls M, et al., New member of the winged-helix protein family disrupted in mouse and rat nude mutations. Nature. 1994 Nov 3;372(6501):103-7
• ID
  MGI:45611

Genes

Gene	Allele	Assay Type	Description
Foxn1	Foxn1^nu	direct sequencing	Hfh11 genomic1, Hfh11 genomic2

Notes

• Reference
  Authors use DD240, DD244, and whn for locus symbols D11Bhm1, D11Bhm3, and Hfh11 respectively.
• Experiment
  By comparing the Foxn1 genomic sequence from wild type (C57BL/6J) and nu mice (C57BL/6JHan-nu) the authors determined that in the nu mouse a single base pair deletion in exon3 causes a frame shift mutation and the subsequent termination of the protein coding region within exon6. This indicates that the nude phenotype results from a deleterious mutation within the Foxn1 gene.