Mapping Data

Experiment

• Experiment
  HYBRID
• Chromosome
  16
• Reference
  J:6319 Cox DR, et al., Genes coding for sensitivity to interferon (IfRec) and soluble superoxide dismutase (SOD-1) are linked in mouse and man and map to mouse chromosome 16. Proc Natl Acad Sci U S A. 1980 Apr;77(4):2168-72
• ID
  MGI:45661

Genes

Gene	Assay Type
Sod1	enzyme activity

Notes

• Experiment
  Somatic cell hybrids were from fusion of Chinese hamster cell line 380-6 with either mouse peritoneal macrophage cells from ICR female mice (n = 10) or cells from male mice homozygous for translocation Rb(16.17)7Bnr (n = 12). The 22 primary hybrid clonesshown in this paper to concordantly segregate Sod-1 and Ifrc were mapped to Chromosome 16. In Rb7 hybrids, Glo-1 segregated with Sod-1 and Ifrc in all but one line suggesting their localization on Chromosome 16 or 17. Glo-1 did not segregate with these loci in the ICR primary clones. Karyotyping of 4 informative ICR hybrids confirmed that Chromosome 16 was the only mouse chromosome concordant with Sod-1 and Ifrc.

HYBRID

• Concordance
  markers

HYBRID Data

Symbols	+/+	+/-	-/+	-/-
Glo1	6	5	1	10