Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:29231 De Sanctis GT, et al., Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet. 1995 Oct;11(2):150-4
• ID
  MGI:45763

Genes

Gene	Assay Type	Description
D17Mit164	PCR amplified length variant	MT3318
Bhr3	visible phenotype
D17Mit177	PCR amplified length variant	MT144

Notes

• Experiment
  Airway hyperresponsiveness in mice is inherited as a polygenic trait in C57BL/6J and A/J mice. The asthma-like phenotype in A/J mice is expressed differently then the phenotype expressed in C57BL/6J mice, therefore allowing for the quantitative mapping (QTL) of this trait in (C57BL/6J x A/J)F1 x C57BL/6J backcross mice. A genome wide scan using Mit markers indicated that one such locus, Bhr3, mapped to mouse Chromosome 17 between D17Mit164 and D17Mit177 with a LOD score of 2.8. An epistatic interaction between Bhr3 and two other hyperresponsive loci located on Chromosomes 2 and 15 may decrease the LOD score of Bhr3.
  
  Bhr3 interacts with Bhr1 and Bhr2. Homozygosity for C57BL/6J-derived alleles at either Bhr1 or Bhr3 confers simlilar decrease in airway hyperresponsiveness as homozygosity at both Bhr1 and Bhr3.
  
  Heterozygosity at either Bhr2 or Bhr3 confers similar increase in airway hyperresponsiveness as heterozygosity at both Bhr2 and Bhr3.