Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:27733 Nagase H, et al., Distinct genetic loci control development of benign and malignant skin tumours in mice. Nat Genet. 1995 Aug;10(4):424-9
• ID
  MGI:45836

Genes

Gene	Assay Type	Description
Skts3	visible phenotype
D5Mit77	PCR amplified length variant	MPC5782
D5Mit1	PCR amplified length variant
Il6	reported elsewhere
Fgfr3	reported elsewhere

Notes

• Experiment
  Susceptibility to skin papillomas in mice was analyzed in a backcross panel of 326 mice derived from (NIH female x M. spretus male)F1 female mice mated back to NIH male mice. Parental strain M. spretus is resistant to skin papilloma formation compared toparental strain NIH. 133 microsatellite markers were screened. Using MAPMAKER/QTL, significant linkage (Mann-Whitney U test) of Skts3 with D5Mit77 (24 cM, lod 3.71) was observed on mouse Chromosome 5. Multiple regression analysis supports the evidence fora locus on mouse Chromosome 5. Linkage to reduced tumor progression mapped to 5 cM near D5Mit1 (lod 4.13). This locus may be identical to Skts3. Potential candidate genes found near this locus are Il6 (17 cM) and Fgfr3 (20 cM).