Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:27733 Nagase H, et al., Distinct genetic loci control development of benign and malignant skin tumours in mice. Nat Genet. 1995 Aug;10(4):424-9
• ID
  MGI:45837

Genes

Gene	Assay Type	Description
Skts1	visible phenotype
D7Mit87	PCR amplified length variant	MPC572
Skts2	visible phenotype
D7Mit43	PCR amplified length variant	A671
Igf1r	reported elsewhere
Fah	reported elsewhere
Fgfr2	reported elsewhere
Hras	reported elsewhere

Notes

• Experiment
  Susceptibility to skin papillomas in mice was analyzed in a backcross panel of 326 mice derived from (NIH female x M. spretus male)F1 female mice mated back to NIH male mice. Parental strain M. spretus is resistant to skin papilloma formation compared toparental strain NIH. 133 microsatellite markers were screened. Using MAPMAKER/QTL, significant linkage (Mann-Whitney U test) of Skts1 with D7Mit87 (27.8 cM, lod 6.99) and Skts2 with D7Mit43 (64 cM, lod 5.77) was observed on mouse Chromosome 7. The linkage of Skts2 with D7Mit43 was observed in female mice only. Multiple regression analysis supports the evidence for two loci on mouse Chromosome 7. Potential candidate genes mapping near Skts1 are Igf1r (33 cM) and Fah (42.6 cM). Potential candidate genes mapping near Skts2 are Fgfr2 (63 cM) and Hras1 (72.2 cM).