Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  16
• Reference
  J:24435 Mori N, et al., Genetic dissection of susceptibility to radiation-induced apoptosis of thymocytes and mapping of Rapop1, a novel susceptibility gene. Genomics. 1995 Feb 10;25(3):609-14
• ID
  MGI:45931

Genes

Gene	Assay Type
D16Mit32	PCR amplified length variant
D16Mit81	PCR amplified length variant
D16Mit34	PCR amplified length variant
Rapop1	visible phenotype

Notes

• Experiment
  Susceptibility to cell death (apoptosis) varies significantly between the inbred strains BALB/cHeA (resistant) and STS/A (susceptible), therefore recombinant congenic strains derived from these inbreds will be informative for identifying chromosome regions contributing to the cell death phenotype. Analysis of the strain distribution patterns of 20 recombinant congenic strains derived from the BALB/cHeA and STS/A progenitors suggests that loci on proximal Chr 16 segregated with the apoptosis phenotype. In an F2 cross involving recombinant congenic strain CcS-7 with progenitor inbred BALB/cHeA a highly significant association was found in the region of mouse Chromosome 16 including the D16Mit32, D16Mit81, and D16Mit34 loci. The symbol assigned for the phenotype is Rapop1 and can be considered a quantitative trait.