Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:31759 Rozmahel R, et al., Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor [published erratum appears in Nat Genet 1996 May;13(1):129]. Nat Genet. 1996 Mar;12(3):280-7
• ID
  MGI:46359

Genes

Gene	Assay Type
Cfm1	visible phenotype
D7Mit152	PCR amplified length variant
D7Mit56	PCR amplified length variant
D7Mit191	PCR amplified length variant
D7Mit83	PCR amplified length variant
D7Mit7	PCR amplified length variant

Notes

• Experiment
  The authors generated a homozygous Cftr insertional mutation line by crossing 129/Sv mutant males with CD1 females and intercrossing to make homozygous mutant animals (Cftr ^m1HSC). Simple sequence length polymorphisms of two classes of mutant animals, varying in longevity, were used to map a Cftr genetic modulatory locus to Chromosome 7. Markers D7Mit152 and D7Mit56 showed significant deviation from the expected random segregation of CD1 and 129/Sv alleles. Class III animals (living over 6 weeks) demonstrated a predominance of the Cd1 derived allele, where as class I animals (living less than 10 days) showed a preponderance of the 129/Sv allele. The order and distances of the mapped loci were reported as follows: Cftrm - D7Mit152 - 1.7 cM - D7Mit56 - 1.2 cM - D7Mit191 - 1.7 cM - D7Mit83 - 1.7 cM - D7Mit7.