Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  4
• Reference
  J:29661 Herzog CR, et al., Allelic loss of distal chromosome 4 in mouse lung tumors localize a putative tumor suppressor gene to a region homologous with human chromosome 1p36. Oncogene. 1995 Nov 2;11(9):1811-5
• ID
  MGI:46420

Genes

Gene	Assay Type
D4Mit77	PCR amplified length variant
Tsp1	resistance/susceptibility
D4Mit251	PCR amplified length variant
D4Mit54	PCR amplified length variant
D4Mit158	PCR amplified length variant
Tsp2	resistance/susceptibility
D4Mit170	PCR amplified length variant

Notes

• Experiment
  Lung tumors obtained from (A/J x C3H/HeJ)F1 and (C3H/HeJ x A/J)F1 mice were analyzed for allele loss (LOH) at various SSLP markers on distal mouse Chromosome 4. The authors indicated that a 3 cM region of mouse Chromosome 4, flanked proximally by SSLP marker D4Mit251 and distally by D4Mit170, included a mouse lung tumor suppressor locus, Tsp2. The mouse tumor suppressor region included markers D4Mit54 and D4Mit158. Futhermore, another mouse lung tumor suppressor locus, Tsp1 was indicated as mapping to a region near D4Mit77 at a distance of approximately 30 cMs from Tsp1.