Mapping Data

Experiment

• Experiment
  TEXT-Congenic
• Chromosome
  2
• Reference
  J:31355 Moen CJ, et al., Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1082-6
• ID
  MGI:46452

Genes

Gene	Assay Type
Hc	reported elsewhere
D2Mit7	PCR amplified length variant
Scc2	visible phenotype
D2Mit9	PCR amplified length variant
D2Mit66	PCR amplified length variant
Ptprj	visible phenotype
D2Nds1	PCR amplified length variant
Cd44	reported elsewhere
Il1	reported elsewhere

Notes

• Reference
  MGD cited.
• Experiment
  Susceptibility to DMH induced colon cancer (Scc) was analyzed in CcS recombinant congenic strains and various backcross populations involving BALB/cHeA (resistant) and CcS mice which carry varying segments of STS/A (susceptible) chromosomes. Previously defined tumor susceptibility genes were eliminated as candidates for the Scc phenotype, these include Kras1, Mlh1, Trp53, Msh2, Mcc, Dcc and Apc. Linkage analysis using progeny from backcross populations involving Ccs-16, Ccs-17 and Ccs-19 indicated that Scc1 maps to a 31 cM region flanked by Hc and Il1. Fine mapping using Ccs-19 revealed an additional susceptibility locus, Scc2 mapping to a region including D2Mit7, additionally the Ptprj position was refined to a 7.7 cM region flanked by D2Mit9 and Cd44 near D2Nds1.