Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  6
• Reference
  J:33172 Yui MA, et al., Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits. Mamm Genome. 1996 May;7(5):331-4
• ID
  MGI:46668

Genes

Gene	Assay Type
Idd6	resistance/susceptibility
D6Mit10	PCR amplified length variant
D6Mit13	PCR amplified length variant
D6Mit14	PCR amplified length variant

Notes

• Experiment
  Microsatellite sequences were used as co-dominant markers to identify/map NOD mouse intervals containing recessive susceptibility alleles of insulin-related diabetes-associated genes. These intervals were transferred to C57BL/6, a resistant strain background, to produce 6 congenic strains. A gain of phenotype strategy was used in their construction. Strain B6.NODc6 contains peak map locations for IDD susceptibility at Idd6; associated markers, in order, were D6Mit10 - D6Mit13a - D6Mit14 (over 24 cM on mouse Chromosome 6).