Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  8
• Reference
  J:33012 Campbell DB, et al., Chromosomal localization of the neurological mouse mutations tottering (tg), Purkinje cell degeneration (pcd), and nervous (nr). Brain Res Mol Brain Res. 1996 Apr;37(1-2):79-84
• ID
  MGI:46770

Genes

Gene	Assay Type	Description
D8Mit155	PCR amplified length variant	MT516
nr	visible phenotype
D8Mit60	PCR amplified length variant	MPC1412
D8Mit16	PCR amplified length variant	D100
D8Mit143	PCR amplified length variant	MT1258
D8Mit171	PCR amplified length variant	MT2053
D11Mit1003	PCR amplified length variant	D619
D8Mit96	PCR amplified length variant	MPC1488

Notes

• Reference
  Authors show D13Mit67 as segregating in mouse Chromosome 13, however subsequent analysis using the mouse genome assembly show this marker mapping with mosue Chromosome 10.
• Experiment
  The nr mutant phenotype was discovered on the BALB/cGR strain and has been backcrossed onto the C3HeB/FeJ strain for 39 generations. Several MIT primer pairs reported to distinguish BALB/c and C3H/HeJ were tested assuming that these SSLP's would also exist between BALB/cGR and C3HeB/FeJ. Several MIT markers were found to be polymorphic between two strains, placing the nr locus in a 2.2 - 5.6 cM interval between D8Mit155 and D8Mit18 on mouse Chromosome 8. These data further defined the following order of loci on mouse Chromosome 8: D8Mit155 - 3.4 cM - nr - D8Mit60 - 2.2 cM - D8Mit16 - D8Mit143 - D8Mit171 - D8Mit18 - 2.8 cM - D8Mit96.