Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  8
• Reference
  J:33012 Campbell DB, et al., Chromosomal localization of the neurological mouse mutations tottering (tg), Purkinje cell degeneration (pcd), and nervous (nr). Brain Res Mol Brain Res. 1996 Apr;37(1-2):79-84
• ID
  MGI:46771

Genes

Gene	Allele	Assay Type	Description
D8Mit180		PCR amplified length variant	MT2712
D8Mit103		PCR amplified length variant	MMH129
Cacna1a	Cacna1a^tg	visible phenotype
D8Mit75		PCR amplified length variant	MPC1768
D8Mit77		PCR amplified length variant	MPC374
D8Mit102		PCR amplified length variant	MT314
D8Mit104		PCR amplified length variant	MPC2609
D8Mit134		PCR amplified length variant	MT239
D8Mit135		PCR amplified length variant	MT876
D8Mit195		PCR amplified length variant	MT2416
D8Mit234		PCR amplified length variant	MT4005
D8Mit249		PCR amplified length variant	MT3583
D8Mit263		PCR amplified length variant	MT5323
D8Mit305		PCR amplified length variant	MTH1439
D8Mit306		PCR amplified length variant	MT5315
D8Mit78		PCR amplified length variant	MPC427
D8Mit106		PCR amplified length variant	MPC1013
D8Mit236		PCR amplified length variant	MJ4621
D8Mit238		PCR amplified length variant	MT4151
D8Mit265		PCR amplified length variant	MT4578
D8Mit79		PCR amplified length variant	MPC917
D8Mit105		PCR amplified length variant	MPC651
D8Mit283		PCR amplified length variant	MTH675
D8Mit45		PCR amplified length variant	B127

Notes

• Reference
  Authors show D13Mit67 as segregating in mouse Chromosome 13, however subsequent analysis using the mouse genome assembly show this marker mapping with mosue Chromosome 10.
• Experiment
  The tg mutant phenotype was discovered on the DBA/2J strain and has since been bred onto the C57BL/6J strain for 35 generations. Several MIT markers reported to be polymorphic between C57BL/6J and DBA/2J were tested in order to distinguish between C57BL/6J-tg, C57BL/6J and DBA/2J. This study placed the tg locus within a 1.1 cM region on mouse Chromosome 8 distal to D8Mit103 and proximal to D8Mit79, D8Mit105 and D8Mit283. Additionally, this analysis also mapped the following order of loci to mouse Chromosome 8: D8Mit180 - 2.3 cM - D8Mit103 - Cacna1a - D8Mit75 - D8Mit77 - D8Mit102 - D8Mit104 - D8Mit134 - D8Mit135 - D8Mit195 - D8Mit234 - D8Mit249 - D8Mit263 - D8Mit305 - D8Mit306 - 1.1 cM - D8Mit78 - D8Mit106 - D8Mit236 - D8Mit238 - D8Mit265 - D8Mit79 - D8Mit105- D8Mit283 - 1.1 cM - D8Mit45.