Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:29218 Manenti G, et al., Different susceptibility to lung tumorigenesis in mice with an identical Kras2 intron 2. Genomics. 1995 Sep 20;29(2):438-44
• ID
  MGI:46825

Genes

Gene	Assay Type	Description
D6Mit12	reported elsewhere
Pas17	resistance/susceptibility
Kras	Southern analysis	codon 61
D6Mit14	reported elsewhere
D6Mit15	reported elsewhere
D6Int1	reported elsewhere

Notes

• Experiment
  Analysis of male progeny from a (A/J x M. spretus)F1 x C57BL/6JBy backcross were analyzed. Interval mapping and quantitative trait linkage was used to map Pas1 to a 18 cM region on mouse Chromosome 6 between marker D6Mit12 and the cosegregating markers Kras, D6Mit14, D6Mit15 and D6Int1.
  
  12.15.2015 Curator Note: Because Pas1 was orginally mapped in J:17778, in 1997 using an (C57BL/6J x A/J)F2 intercross which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Pas17.
  
  Susceptibility to lung carcinogenesis was attributed to the mice carrying the A/J allele. Pas17 peaked at Kras2 with a LOD score higher than 8.0; accounting for 34% of the total phenotypic variablity.