Mapping Data

Experiment

• Experiment
  TEXT-Congenic
• Chromosome
  3
• Reference
  J:28947 Mcaleer MA, et al., Crosses of NOD mice with the related NON strain: A polygenic model for IDDM. Diabetes. 1995 OCT;44(10):1186-1195
• ID
  MGI:46885

Genes

Gene	Assay Type
Idd3	resistance/susceptibility
Il2	reported elsewhere
Idd10	resistance/susceptibility
Tshb	reported elsewhere

Notes

• Reference
  Author suggest that Il2, Fcgr1, Nramp1 and Tnfr2 may be candidate genes for Idd3, Idd10, Idd5 and Idd9 respectively.
• Experiment
  Analysis of 82 (NOD/Lt x NON.H2^g7)F2 intercross and 245 (NOD/Lt x NON.H2^g7)F1 x NOD/Lt backcross progeny indicate that the development of spontaneous diabetes (Idd3) is linked to Il2 (P = 0.0017 for backcross progeny, P = 0.064 for intercross progeny) on mouse Chromosome 3. Further analysis of the 82 intercross progeny show that Idd10 is statistically linked to Tshb, P = 0.044.