Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:33277 Melo JA, et al., Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/ 6 mice. Nat Genet. 1996 Jun;13(2):147-53
• ID
  MGI:47182

Genes

Gene	Assay Type
D2Mit293	PCR amplified length variant
D2Mit241	PCR amplified length variant
Alcp1	visible phenotype
D2Mit125	PCR amplified length variant
D2Mit436	PCR amplified length variant

Notes

• Experiment
  Backcross progeny from crosses between (C57BL/6J x DBA/2J)F1 females x C57BL/6J males (N = 262) and C57BL/6J females x (C57BL/6J x DBA/2J)F1 males (N = 73) were analyzed for alcohol consumption. The difference in alcohol consumption between male and female backcross progeny is significant at a P value of 0.00004, therefore sexes were analyzed separately using chi-square analysis to find quantitative trait loci (QTL). A region of mouse Chromsome 2 bounded proximally by D2Mit241 and distally by D2Mit125 was associated with alcohol consumption in male mice and given the symbol Alcp1. The genetic distances between the informative microsatellite loci were as follows: D2Mit293 - 16 cM - D2Mit241 - 15 cM - D2Mit125 - 6 cM - D2Mit436.
  
  Male animals homozygous for C57BL/6J-derived alleles at Alcp1 exhibit increased alcohol consumption compared to heterozygous animals.