Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:33277 Melo JA, et al., Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/ 6 mice. Nat Genet. 1996 Jun;13(2):147-53
• ID
  MGI:47183

Genes

Gene	Assay Type
D11Mit140	PCR amplified length variant
D11Mit219	PCR amplified length variant
Alcp2	visible phenotype
D11Mit40	PCR amplified length variant
D11Mit195	PCR amplified length variant
D11Mit199	PCR amplified length variant

Notes

• Experiment
  Backcross progeny from crosses between (C57BL/6J x DBA/2J)F1 females x C57BL/6J males (N = 262) and C57BL/6J females x (C57BL/6J x DBA/2J)F1 males (N = 73) were analyzed for alcohol consumption. The difference in alcohol consumption between male and female backcross progeny is significant at a P value of 0.00004, therefore sexes were analyzed separately using chi-square analysis to find quantitative trait loci (QTL). A region of mouse Chromsome 11 bounded proximally by D11Mit219 and distally by D11Mit195was associated with alcohol consumption in female mice and given the symbol Alcp2. The genetic distances between the informative microsatellite loci were as follows: D11Mit140 - 13 cM - D11Mit219 - 3 cM - D11Mit40 - 5 cM - D11Mit195 - 12 cM - D11Mit199. In addition it was observed that the Alcp2 phenotype is significantly expressed only in female backcross progeny derived from a paternal C57BL/6J.
  
  Female animals having a C57BL/6J father and are homozygous for C57BL/6J-derived alleles at Alcp2 exhibit increased alcohol consumption.