Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  17
• Reference
  J:29073 Ikegami H, et al., Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping. J Clin Invest. 1995 Oct;96(4):1936-42
• ID
  MGI:47202

Genes

Gene	Assay Type	Description
D11Mit1000	PCR amplified length variant	MT2997
Idd16	resistance/susceptibility
H2-Oa	PCR amplified length variant	D17Dgm3-pA, D17Dgm3-pB
Idd1	resistance/susceptibility
Hspa1b	PCR amplified length variant	28.MMHSP68C
D17Mit50	PCR amplified length variant	B619

Notes

• Reference
  Candidate genes for Idd16 and Idd1 are Tnfa or Sod2 and Il2 respectively.
• Experiment
  Analysis of congenic strains NOD.CTS-H2 and NOD.NON-H2 suggests that Idd1 is encoded by two or more loci on mouse Chromosome 17; one componet mapping in a 0.5 cM range encompassing H2-Oa and Hspa1b and the other component mapping outside the class II E and A region. In comparing Chromosome 17 of the congenic NOD.CTS-H2 with NOD and CTS, authors found a second gene (Idd16) responsible for up to 90% reduction in the Idd incidence. This gene is located in either a 7.6 cM region proximal to H2-Oa (bounded by, but not inclusive of D17Mit144) or a 3.4 cM region distal to Hspa1b (bounded by, but inclusive of D17Mit50).