Mapping Data

Experiment

• Experiment
  TEXT-Cytogenetic Localization
• Chromosome
  2
• Reference
  J:34062 Zhuang SM, et al., Allelotype analysis of 2',3'-dideoxycytidine- and 1,3-butadiene-induced lymphomas in B6C3F1 mice. Cancer Res. 1996 Jul 15;56(14):3338-43
• ID
  MGI:47313

Genes

Gene	Assay Type
D2Mit147	PCR amplified length variant
Tsp3	resistance/susceptibility
D2Mit148	PCR amplified length variant

Notes

• Reference
  MGD cited. Authors use p53 for locus symbol Trp53.
• Experiment
  A loss of heterozygocity has often been found to accompany inactivation of tumor suppressor genes. To that end, authors analyzed the loss of somatic cell heterozygocity in chemically induced tumor tissue using simple sequence length polymorphism (SSLP) analysis to localize suppressor gene candidates. Frequent allelic losses were associated with markers on mouse Chromosome 2. Tsp3, a 3 cM region D2Mit147 and D2Mit148 was indicated as a potential site of a tumor suppressor gene.