Mapping Data

Experiment

• Experiment
  TEXT-Cytogenetic Localization
• Chromosome
  4
• Reference
  J:34062 Zhuang SM, et al., Allelotype analysis of 2',3'-dideoxycytidine- and 1,3-butadiene-induced lymphomas in B6C3F1 mice. Cancer Res. 1996 Jul 15;56(14):3338-43
• ID
  MGI:47314

Genes

Gene	Assay Type
D4Wsm1	reported elsewhere
Tsp4	resistance/susceptibility
D4Mit187	PCR amplified length variant
D4Mit204	PCR amplified length variant
Tsp5	resistance/susceptibility

Notes

• Reference
  MGD cited. Authors use p53 for locus symbol Trp53.
• Experiment
  A loss of heterozygocity has often been found to accompany inactivation of tumor suppressor genes. To that end, authors analyzed the loss of somatic cell heterozygocity in chemically induced tumor tissue using simple sequence length polymorphism (SSLP) analysis to localize suppressor gene candidates. Frequent allelic losses were associated with markers on mouse Chromosome 4. At least two deletion units were found to exist on this chromosome. The proximal region (Tsp4) spans the Ifa gene cluster of about 12 cM, bounded by D4Wsm1 and D4Mit187 and the telomeric region Tsp5 was reported to reside distal to D4Mit204.