Mapping Data

Experiment

• Experiment
  TEXT-Cytogenetic Localization
• Chromosome
  11
• Reference
  J:34062 Zhuang SM, et al., Allelotype analysis of 2',3'-dideoxycytidine- and 1,3-butadiene-induced lymphomas in B6C3F1 mice. Cancer Res. 1996 Jul 15;56(14):3338-43
• ID
  MGI:47315

Genes

Gene	Assay Type
Chrnb1	reported elsewhere
Tsp6	resistance/susceptibility

Notes

• Reference
  MGD cited. Authors use p53 for locus symbol Trp53.
• Experiment
  A loss of heterozygocity has often been found to accompany inactivation of tumor suppressor genes. To that end, authors analyzed the loss of somatic cell heterozygocity in chemically induced tumor tissue using simple sequence length polymorphism (SSLP) analysis to localize suppressor gene candidates. Frequent allelic losses were associated with markers on mouse Chromosome 11. All tumors with allelic losses on mouse Chromosome 11 lost one allele (Tsp6) at the Acrb locus which lies within 1 cM Trp53. Trp53was suggested to be the likely target gene.