Mapping Data

Experiment

• Experiment
  TEXT-Cytogenetic Localization
• Chromosome
  12
• Reference
  J:34062 Zhuang SM, et al., Allelotype analysis of 2',3'-dideoxycytidine- and 1,3-butadiene-induced lymphomas in B6C3F1 mice. Cancer Res. 1996 Jul 15;56(14):3338-43
• ID
  MGI:47316

Genes

Gene	Assay Type
D12Mit263	PCR amplified length variant
Tsp7	resistance/susceptibility
D12Nds2	reported elsewhere

Notes

• Reference
  MGD cited. Authors use p53 for locus symbol Trp53.
• Experiment
  A loss of heterozygocity has often been found to accompanyy inactivation of tumor suppressor genes. To that end, authors analyzed the loss of somatic cell heterozygocity in chemically induced tumor tissue using simple sequence length polymorphism (SSLP) analysis to localize suppressor gene candidates. Frequent allelic losses were associated with markers on mouse Chromosome 12. ON mouse Chromosome 12, a ~2 cM region (Tsp7) between markers D12Mit263 and D12Nds2 was indicated to be the likely location of a tumor suppressor locus invloved in lymphogenesis.