Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  10
• Reference
  J:35521 Horvat S, et al., The high growth (hg) locus maps to a deletion in mouse chromosome 10. Genomics. 1996 Sep 15;36(3):546-9
• ID
  MGI:47425

Genes

Gene	Allele	Assay Type
D10Mit68		PCR amplified length variant
D10Mit41		PCR amplified length variant
D10Mit177		PCR amplified length variant
D10Mit69		PCR amplified length variant
Socs2	Socs2^hg	visible phenotype
D10Mit119		PCR amplified length variant

Notes

• Experiment
  Authors report that the marker D10Mit69 is deleted in Socs2^hg mice. To further investigate this, authors preformed a cross between congenic strains C57BL/6J-Socs2^hg/Socs2^hg x C57BL/6J and constructed a high-resolution map of microsatellite markers based upon the genotypes of the mice typed from this cross. From this analysis the following order of loci was determined: D10Mit68 - 0.5 cM - D10Mit41 - D10Mit177 - 0.1 cM - D10Mit69 - D10Mit119. Further analysis showed that hg and D10Mit69 cosegregate in the cross, suggesting that the deletion around D10Mit69 is responsible for the high growth (hg) effect. The authors indicate that D10Mit69 and D10Mit199 are separated by a genetic distance less than 0.23 cM, suggesting that the deleted segment is relatively small.