Mapping Data

Experiment

• Experiment
  TEXT-Congenic
• Chromosome
  3
• Reference
  J:3351 Todd JA, et al., Genetic analysis of autoimmune type 1 diabetes mellitus in mice [see comments]. Nature. 1991 Jun 13;351(6327):542-7
• ID
  MGI:47593

Genes

Gene	Assay Type
D3Nds1	PCR amplified length variant
Idd3	visible phenotype
Tshb	reported elsewhere

Notes

• Experiment
  Analysis of reciprocal congenic strains involving a segment of mouse Chromosome 17 indicated that non - H2 genes were involved in the onset of autoimmune type 1 diabetes in NOD mice. In female mice derived from (B10.H2^g7 congenic x NOD)F1 x NOD backcross a significant chi square association of mouse Chromosome 3 loci D3Nds1 and Tshb with diabetes was observed. The marker symbol Idd3 is provided for the segment on mouse Chromosome 3 associated with autoimmune type 1 diabetes in NOD mice. in the F1 congenic partner in the backcross carries NOD alleles for Idd1 therefore eliminating that marker as a variable for diabetes in the offspring.