Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:36255 Gorham JD, et al., Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12467-72
• ID
  MGI:47607

Genes

Gene	Assay Type
Tcpm1	immunological
D11Mit111	PCR amplified length variant
D11Mit274	PCR amplified length variant

Notes

• Experiment
  A single dominant genetic locus controls T-cell maintenance of Il-12 reponsiveness in mice. The genetic location of this locus, Tcpm1 (T-cell phenotype modifier 1), was determined using quantitative trait analysis (QTL) of loci in a backcross between (B10.D2/nSnJ x BO11.10)F1 x BALB/c mice. BO11.10 mice carry Tcr transgenes on a BALB/c background. 197 polymorphic markers at an average spacing of 10 cM were used for the genome scan. The most likely location of Tcpm1 is between D11Mit111 (27.9 cM) and D11Mit274 (30 cM) (LOD=6.5). Tcpm1 exhibits 83% penetrance. BALB/c-derived alleles at Tcpm1 are associated with maintenence of IL-12 responsiveness in T-cells.