Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  3
• Reference
  J:35330 Maeda YY, et al., Two genes controlling acute phase responses by the antitumor polysaccharide, lentinan. Immunogenetics. 1996;43(4):215-9
• ID
  MGI:47663

Genes

Gene	Assay Type
ltnr1	resistance/susceptibility
D3Mit11	PCR amplified length variant

Notes

• Experiment
  The lentinan resistant phenotype (in which mice show no acute phase protein increase in response to lentinan) was determined to be a recessive trait in high-responder SWR/J and low-responder SRP/J mice. Twenty four N2 progeny of a (SWR/J xSPR/J)F1 x SWR/J cross were randomlly selected for typing 80 chromosome-specific microsatellite loci for PCR methods. Linkage analysis between each microsatellite locus and lentinan resistant phenotype presented chromosomal segments meeting the authors criteria for significant evidence of linkage to the delayed type of acute phase protein response (DT-APR). ltnr1 was closely linked to D3Mit11 on mouse Chromosome 3.