Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  11
• Reference
  J:35330 Maeda YY, et al., Two genes controlling acute phase responses by the antitumor polysaccharide, lentinan. Immunogenetics. 1996;43(4):215-9
• ID
  MGI:47664

Genes

Gene	Assay Type
ltnr2	resistance/susceptibility
D11Nds9	PCR amplified length variant

Notes

• Experiment
  The lentinan resistant phenotype (in which mice show no acute phase protein increase in response to lentinan) was determined to be a recessive trait in high-responder SWR/J and low-responder SRP/J mice. Twenty four N2 progeny of a (SWR/J xSPR/J)F1 x SWR/J cross were randomlly selected for typing 80 chromosome-specific microsatellite loci for PCR methods. Linkage analysis between each microsatellite locus and lentinan resistant phenotype presented chromosomal segments meeting the authors criteria for significant evidence of linkage to the delayed type of acute phase protein response (DT-APR). ltnr2 was closely linked to D11Nds9 on mouse Chromosome 11.