Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  10
• Reference
  J:36348 Guay-Woodford LM, et al., Evidence that two phenotypically distinct mouse PKD mutations, bpk and jcpk, are allelic. Kidney Int. 1996 Oct;50(4):1158-65
• ID
  MGI:47881

Genes

Gene	Allele	Assay Type
Bicc1	Bicc1^jcpk-bpk	visible phenotype

Notes

• Reference
  Authors map bpk in close vicinity to jcpk but state that they are currently unable to determine whether the jcpk phenotype results from disruptions in the same locus as bpk or whether it involves two closely linked genes, one of which is bpk.
• Experiment
  To test whether bpk and jcpk mutations are allelic on mouse Chromosome 10, test-proven +/bpk and +/jcpk heterozygotes were crossed. Six of 19 pups demonstrated both recessive mutations. Given that both bpk and jcpk are recessive mutations, the expression of a mutant phenotype in approximately one quarter of F1 offspring indicates that these mutations are allelic.