Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  15
• Reference
  J:37522 Pace JM, et al., Disproportionate micromelia (Dmm) in mice caused by a mutation in the C-propeptide coding region of Col2a1. Dev Dyn. 1997 Jan;208(1):25-33
• ID
  MGI:47945

Genes

Gene	Allele	Assay Type
Col2a1	Col2a1^Dmm	visible phenotype
D15Mit42		SSLP
D15Mit48		SSLP
D15Mit172		SSLP

Notes

• Reference
  Authors determined that Dmm is the result of a 3 nucleotide deletion in the C-propeptide domain of Col2a1, therefor Dmm is an allele at the Col2a1 locus.
• Experiment
  Authors typed 18 Col2a1^Dmm homozygous mice from a (Col2a1^Dmm/+ x C58/J)F2 intercross in order to determine the linkage of selected loci on mouse Chromosome 15. D15Mit48 and D15Mit172 exhibit significant linkage to Col2a1^Dmm with LOD scores of 7.7 and 4.3 respectively. Additionally authors report that D15Mit42 maps approximately 1 cM distal of Col2a1 with a LOD score of 11.44.