Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  18
• Reference
  J:36996 van Wezel T, et al., Gene interaction and single gene effects in colon tumour susceptibility in mice [see comments]. Nat Genet. 1996 Dec;14(4):468-70
• ID
  MGI:47963

Genes

Gene	Assay Type
Scc5	resistance/susceptibility
D18Mit57	PCR amplified length variant

Notes

• Experiment
  QTL analysis of 192 (BALB/c x Ccs-19)F2 mice revealed a new colon tumor susceptibility locus, Scc5, tightly linked to D18Mit57 on mouse Chromosome 18 (P = 0.25). Authors note that Scc4 and Scc5 have no apparent individual effect, but that they show a strong reciprocal interaction (P = 0.0064).
  
  Authors suggest Tgfb2, Msh2, Apc and Grl1 as possible candidate genes for Scc2, Scc3, Scc4 and Scc5 respectively.