Mapping Data

Experiment

• Experiment
  CROSS
• Chromosome
  1
• Reference
  J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
• ID
  MGI:48079

Genes

Gene	Assay Type	Description
D1Mit4	PCR amplified length variant
D1Ucla1	reported elsewhere
Pou3f3	reported elsewhere
D1Ucla5	reported elsewhere
D1Mit22	PCR amplified length variant
Stradb	reported elsewhere
Cps1	reported elsewhere
Chrnd	reported elsewhere
D1Ucla6	reported elsewhere
D1Mit9	PCR amplified length variant
Hdlbp	reported elsewhere
Ptgs2	reported elsewhere
D1Ucla7	reported elsewhere
D1Mit14	PCR amplified length variant
Soat1	Southern analysis	pHuACAT1.6
Rxrg	reported elsewhere
Serpinc1	reported elsewhere
Sell	reported elsewhere
Fcgr2b	reported elsewhere
Apoa2	reported elsewhere
Crp	reported elsewhere
D1Ucla8	reported elsewhere
Dcaf8	reported elsewhere
Spta1	reported elsewhere
D1Mit17	reported elsewhere

Notes

• Reference
  The marker maps experimentally derived in this paper were overlapped with published maps for a number of QTL regions associated with plasma total cholesterol (Chromosomes 1, 5, 6, 7, 12, 15 ,18), plasma HDL cholesterol (Chromosomes 1, 5, 7, 17), plasma LDL/VLDL cholesterol (Chromosomes 9, 12, 13, 15), plasma triglyceride (Chromosomes 5, 7), gallstones (Chromosome 2), and obesity (Chromosomes 4, 6, 7, 9, 12, 15). Authors use Lipc, Brn3.1, Ghrhrr, Gad-1ps, Otf11, Sel1, Tcfcoup2, Crfr, Brn5.0, G6pd, Otf9, Igl1, Pgs1, Lgals1 and Lgals2 for locus symbols Hpl, Pou4f3, Ghrhr, Gad1-ps, Pou2f3, DSell, Aporp1, Crhr, Pou6f1, G6pdx, Pou3f4, Igl-5, Ptgs1, Lgals4 and Lgals6 respectively.

CROSS

• Type
  Backcross, female
• Female Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>/<s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s>
• Strain
  (C57BL/6J x M. spretus)F1
• Male Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>/<b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>
• Strain
  C57BL/6J
• Mapping Panel
  UCLA (BSB)
• Allele 1
  b from C57BL/6J
• Allele 2
  s from M. spretus

2x2 Data Reported

Marker 1	Marker 2	# Recombinants	# Parentals
D1Mit4	D1Ucla1	1	52
D1Ucla1	Pou3f3	1	46
Pou3f3	D1Ucla5	2	62
D1Ucla5	D1Mit22	1	58
D1Ucla5	D1Ucla1	1	58
D1Mit22	Cps1	4	59
Stradb	Cps1	4	59
Cps1	Chrnd	3	60
Cps1	D1Ucla6	3	60
Cps1	D1Mit9	3	60
Chrnd	D1Ucla6	0	51
Chrnd	D1Mit9	0	51
D1Ucla6	D1Mit9	0	51
Chrnd	Hdlbp	2	49
D1Ucla6	Hdlbp	2	49
D1Mit9	Hdlbp	2	49
Hdlbp	Ptgs2	8	58
Ptgs2	D1Ucla7	2	63
D1Ucla7	D1Mit14	1	60
D1Mit14	Soat1	1	51
Soat1	Rxrg	2	54
Rxrg	Serpinc1	1	65
Serpinc1	Sell	1	65
Sell	Fcgr2b	4	60
Fcgr2b	Apoa2	1	63
Apoa2	Crp	1	63
Apoa2	D1Ucla8	1	63
Crp	Dcaf8	1	64
D1Ucla8	Dcaf8	1	64
Dcaf8	Spta1	1	64
Spta1	D1Mit17	6	57

Statistics

Marker 1	Marker 2	# Recombinants	Total	% Recombinants	Std Error
D1Mit4	D1Ucla1	1	53	1.887	1.869
D1Ucla1	Pou3f3	1	47	2.128	2.105
Pou3f3	D1Ucla5	2	64	3.125	2.175
D1Ucla5	D1Mit22	1	59	1.695	1.680
D1Ucla5	D1Ucla1	1	59	1.695	1.680
D1Mit22	Cps1	4	63	6.349	3.072
Stradb	Cps1	4	63	6.349	3.072
Cps1	Chrnd	3	63	4.762	2.683
Cps1	D1Ucla6	3	63	4.762	2.683
Cps1	D1Mit9	3	63	4.762	2.683
Chrnd	D1Ucla6	0	51	0.000	0.000
Chrnd	D1Mit9	0	51	0.000	0.000
D1Ucla6	D1Mit9	0	51	0.000	0.000
Chrnd	Hdlbp	2	51	3.922	2.718
D1Ucla6	Hdlbp	2	51	3.922	2.718
D1Mit9	Hdlbp	2	51	3.922	2.718
Hdlbp	Ptgs2	8	66	12.121	4.017
Ptgs2	D1Ucla7	2	65	3.077	2.142
D1Ucla7	D1Mit14	1	61	1.639	1.626
D1Mit14	Soat1	1	52	1.923	1.904
Soat1	Rxrg	2	56	3.571	2.480
Rxrg	Serpinc1	1	66	1.515	1.504
Serpinc1	Sell	1	66	1.515	1.504
Sell	Fcgr2b	4	64	6.250	3.026
Fcgr2b	Apoa2	1	64	1.562	1.550
Apoa2	Crp	1	64	1.562	1.550
Apoa2	D1Ucla8	1	64	1.562	1.550
Crp	Dcaf8	1	65	1.538	1.527
D1Ucla8	Dcaf8	1	65	1.538	1.527
Dcaf8	Spta1	1	65	1.538	1.527
Spta1	D1Mit17	6	63	9.524	3.698