Mapping Data

Experiment

• Experiment
  CROSS
• Chromosome
  2
• Reference
  J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
• ID
  MGI:48080

Genes

Gene	Assay Type	Description
D2Mit6	PCR amplified length variant
Gad2	reported elsewhere
Cel	reported elsewhere
D2Mit65	PCR amplified length variant
Ptgs1	reported elsewhere
Lrp2	Southern analysis	pLRP2
Chrna1	reported elsewhere
D2Mit35	PCR amplified length variant
D2Mit14a	PCR amplified length variant
D2Mit30	PCR amplified length variant
D2Nds3	reported elsewhere
D2Mit19	PCR amplified length variant
D2Ucla2	reported elsewhere
Ergic3	reported elsewhere
a	reported elsewhere
D2Mit22	PCR amplified length variant
D2Mit25	PCR amplified length variant

Notes

• Reference
  The marker maps experimentally derived in this paper were overlapped with published maps for a number of QTL regions associated with plasma total cholesterol (Chromosomes 1, 5, 6, 7, 12, 15 ,18), plasma HDL cholesterol (Chromosomes 1, 5, 7, 17), plasma LDL/VLDL cholesterol (Chromosomes 9, 12, 13, 15), plasma triglyceride (Chromosomes 5, 7), gallstones (Chromosome 2), and obesity (Chromosomes 4, 6, 7, 9, 12, 15). Authors use Lipc, Brn3.1, Ghrhrr, Gad-1ps, Otf11, Sel1, Tcfcoup2, Crfr, Brn5.0, G6pd, Otf9, Igl1, Pgs1, Lgals1 and Lgals2 for locus symbols Hpl, Pou4f3, Ghrhr, Gad1-ps, Pou2f3, DSell, Aporp1, Crhr, Pou6f1, G6pdx, Pou3f4, Igl-5, Ptgs1, Lgals4 and Lgals6 respectively.

CROSS

• Type
  Backcross, female
• Female Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>/<s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s>
• Strain
  (C57BL/6J x M. spretus)F1
• Male Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>/<b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>
• Strain
  C57BL/6J
• Mapping Panel
  UCLA (BSB)
• Allele 1
  b from C57BL/6J
• Allele 2
  s from M. spretus

2x2 Data Reported

Marker 1	Marker 2	# Recombinants	# Parentals
D2Mit6	Gad2	3	60
Gad2	Cel	1	61
Cel	D2Mit65	1	52
D2Mit65	Ptgs1	2	52
Ptgs1	Lrp2	8	57
Lrp2	Chrna1	1	64
Chrna1	D2Mit35	1	65
D2Mit35	D2Mit14a	6	57
D2Mit14a	D2Mit30	8	55
D2Mit30	D2Nds3	3	53
D2Nds3	D2Mit19	1	55
D2Mit19	D2Ucla2	3	63
D2Mit19	Ergic3	3	63
D2Ucla2	Ergic3	0	66
D2Ucla2	D2Mit22	1	65
Ergic3	D2Mit22	1	65
D2Ucla2	a	1	65
Ergic3	a	1	65
D2Mit22	a	0	66
D2Mit22	D2Mit25	8	58
a	D2Mit25	8	58

Statistics

Marker 1	Marker 2	# Recombinants	Total	% Recombinants	Std Error
D2Mit6	Gad2	3	63	4.762	2.683
Gad2	Cel	1	62	1.613	1.600
Cel	D2Mit65	1	53	1.887	1.869
D2Mit65	Ptgs1	2	54	3.704	2.570
Ptgs1	Lrp2	8	65	12.308	4.075
Lrp2	Chrna1	1	65	1.538	1.527
Chrna1	D2Mit35	1	66	1.515	1.504
D2Mit35	D2Mit14a	6	63	9.524	3.698
D2Mit14a	D2Mit30	8	63	12.698	4.195
D2Mit30	D2Nds3	3	56	5.357	3.009
D2Nds3	D2Mit19	1	56	1.786	1.770
D2Mit19	D2Ucla2	3	66	4.545	2.564
D2Mit19	Ergic3	3	66	4.545	2.564
D2Ucla2	Ergic3	0	66	0.000	0.000
D2Ucla2	D2Mit22	1	66	1.515	1.504
Ergic3	D2Mit22	1	66	1.515	1.504
D2Ucla2	a	1	66	1.515	1.504
Ergic3	a	1	66	1.515	1.504
D2Mit22	a	0	66	0.000	0.000
D2Mit22	D2Mit25	8	66	12.121	4.017
a	D2Mit25	8	66	12.121	4.017