Mapping Data

Experiment

• Experiment
  CROSS
• Chromosome
  5
• Reference
  J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
• ID
  MGI:48083

Genes

Gene	Assay Type	Description
Lrpap1	Southern analysis	RAPII 145
D5Mit54	PCR amplified length variant
D5Mit5	PCR amplified length variant
D5Ucla1	reported elsewhere
D5Ucla5	reported elsewhere
D5Ucla2	reported elsewhere
D5Ucla6	reported elsewhere
Hspb8	reported elsewhere
Tpst2	reported elsewhere
Mvk	Southern analysis	SGB-1171
D5Mit65	PCR amplified length variant
Gusb	reported elsewhere

Notes

• Reference
  The marker maps experimentally derived in this paper were overlapped with published maps for a number of QTL regions associated with plasma total cholesterol (Chromosomes 1, 5, 6, 7, 12, 15 ,18), plasma HDL cholesterol (Chromosomes 1, 5, 7, 17), plasma LDL/VLDL cholesterol (Chromosomes 9, 12, 13, 15), plasma triglyceride (Chromosomes 5, 7), gallstones (Chromosome 2), and obesity (Chromosomes 4, 6, 7, 9, 12, 15). Authors use Lipc, Brn3.1, Ghrhrr, Gad-1ps, Otf11, Sel1, Tcfcoup2, Crfr, Brn5.0, G6pd, Otf9, Igl1, Pgs1, Lgals1 and Lgals2 for locus symbols Hpl, Pou4f3, Ghrhr, Gad1-ps, Pou2f3, DSell, Aporp1, Crhr, Pou6f1, G6pdx, Pou3f4, Igl-5, Ptgs1, Lgals4 and Lgals6 respectively.

CROSS

• Type
  Backcross, female
• Female Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>/<s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s>
• Strain
  (C57BL/6J x M. spretus)F1
• Male Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>/<b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>
• Strain
  C57BL/6J
• Mapping Panel
  UCLA (BSB)
• Allele 1
  b from C57BL/6J
• Allele 2
  s from M. spretus

2x2 Data Reported

Marker 1	Marker 2	# Recombinants	# Parentals
Lrpap1	D5Mit54	6	58
D5Mit54	D5Mit5	5	59
D5Mit5	D5Ucla1	7	59
D5Mit5	D5Ucla5	7	59
D5Mit5	D5Ucla2	7	59
D5Ucla1	D5Ucla5	0	61
D5Ucla1	D5Ucla2	0	61
D5Ucla5	D5Ucla2	0	61
D5Ucla1	D5Ucla6	1	63
D5Ucla5	D5Ucla6	1	63
D5Ucla2	D5Ucla6	1	63
D5Ucla6	Hspb8	3	61
Hspb8	Tpst2	2	64
Hspb8	Mvk	2	64
Tpst2	D5Mit65	1	66
Mvk	D5Mit65	1	66
D5Mit65	Gusb	4	59

Statistics

Marker 1	Marker 2	# Recombinants	Total	% Recombinants	Std Error
Lrpap1	D5Mit54	6	64	9.375	3.644
D5Mit54	D5Mit5	5	64	7.812	3.355
D5Mit5	D5Ucla1	7	66	10.606	3.790
D5Mit5	D5Ucla5	7	66	10.606	3.790
D5Mit5	D5Ucla2	7	66	10.606	3.790
D5Ucla1	D5Ucla5	0	61	0.000	0.000
D5Ucla1	D5Ucla2	0	61	0.000	0.000
D5Ucla5	D5Ucla2	0	61	0.000	0.000
D5Ucla1	D5Ucla6	1	64	1.562	1.550
D5Ucla5	D5Ucla6	1	64	1.562	1.550
D5Ucla2	D5Ucla6	1	64	1.562	1.550
D5Ucla6	Hspb8	3	64	4.688	2.642
Hspb8	Tpst2	2	66	3.030	2.110
Hspb8	Mvk	2	66	3.030	2.110
Tpst2	D5Mit65	1	67	1.493	1.481
Mvk	D5Mit65	1	67	1.493	1.481
D5Mit65	Gusb	4	63	6.349	3.072