Mapping Data

Experiment

• Experiment
  CROSS
• Chromosome
  8
• Reference
  J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
• ID
  MGI:48085

Genes

Gene	Assay Type	Description
D8Mit24	PCR amplified length variant
D8Ucla1	reported elsewhere
D8Mit9	PCR amplified length variant
Srebf1	Southern analysis	pCMV-CSA
Hmox1	reported elsewhere
D8Mit11	PCR amplified length variant
Lcat	reported elsewhere
D8Mit14	PCR amplified length variant
D8Ucla2	reported elsewhere

Notes

• Reference
  The marker maps experimentally derived in this paper were overlapped with published maps for a number of QTL regions associated with plasma total cholesterol (Chromosomes 1, 5, 6, 7, 12, 15 ,18), plasma HDL cholesterol (Chromosomes 1, 5, 7, 17), plasma LDL/VLDL cholesterol (Chromosomes 9, 12, 13, 15), plasma triglyceride (Chromosomes 5, 7), gallstones (Chromosome 2), and obesity (Chromosomes 4, 6, 7, 9, 12, 15). Authors use Lipc, Brn3.1, Ghrhrr, Gad-1ps, Otf11, Sel1, Tcfcoup2, Crfr, Brn5.0, G6pd, Otf9, Igl1, Pgs1, Lgals1 and Lgals2 for locus symbols Hpl, Pou4f3, Ghrhr, Gad1-ps, Pou2f3, DSell, Aporp1, Crhr, Pou6f1, G6pdx, Pou3f4, Igl-5, Ptgs1, Lgals4 and Lgals6 respectively.

CROSS

• Type
  Backcross, female
• Female Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b>/<s> <s> <s> <s> <s> <s> <s> <s> <s>
• Strain
  (C57BL/6J x M. spretus)F1
• Male Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b>/<b> <b> <b> <b> <b> <b> <b> <b> <b>
• Strain
  C57BL/6J
• Mapping Panel
  UCLA (BSB)
• Allele 1
  b from C57BL/6J
• Allele 2
  s from M. spretus

2x2 Data Reported

Marker 1	Marker 2	# Recombinants	# Parentals
D8Mit24	D8Ucla1	7	52
D8Ucla1	D8Mit9	5	56
D8Ucla1	Srebf1	5	56
D8Mit9	Srebf1	0	60
D8Mit9	Hmox1	2	47
Srebf1	Hmox1	2	47
Hmox1	D8Mit11	1	44
D8Mit11	Lcat	5	57
Lcat	D8Mit14	8	57
D8Mit14	D8Ucla2	4	60

Statistics

Marker 1	Marker 2	# Recombinants	Total	% Recombinants	Std Error
D8Mit24	D8Ucla1	7	59	11.864	4.210
D8Ucla1	D8Mit9	5	61	8.197	3.512
D8Ucla1	Srebf1	5	61	8.197	3.512
D8Mit9	Srebf1	0	60	0.000	0.000
D8Mit9	Hmox1	2	49	4.082	2.827
Srebf1	Hmox1	2	49	4.082	2.827
Hmox1	D8Mit11	1	45	2.222	2.197
D8Mit11	Lcat	5	62	8.065	3.458
Lcat	D8Mit14	8	65	12.308	4.075
D8Mit14	D8Ucla2	4	64	6.250	3.026