Mapping Data

Experiment

• Experiment
  CROSS
• Chromosome
  12
• Reference
  J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
• ID
  MGI:48089

Genes

Gene	Assay Type
Apob	reported elsewhere
D12Ucla8	reported elsewhere
Rrm2	reported elsewhere
D12Ucla6	reported elsewhere
D12Ucla7	reported elsewhere
D12Mit36	PCR amplified length variant
Fdpsl6	reported elsewhere
Acot1	reported elsewhere
D12Ucla3	reported elsewhere
Serpina1b	reported elsewhere
D12Ucla4	reported elsewhere
D12Ucla9	reported elsewhere
Pre2	reported elsewhere
D12Ucla5	reported elsewhere
D12Mit141	PCR amplified length variant
D12Nds2	reported elsewhere
Igh	reported elsewhere

Notes

• Reference
  The marker maps experimentally derived in this paper were overlapped with published maps for a number of QTL regions associated with plasma total cholesterol (Chromosomes 1, 5, 6, 7, 12, 15 ,18), plasma HDL cholesterol (Chromosomes 1, 5, 7, 17), plasma LDL/VLDL cholesterol (Chromosomes 9, 12, 13, 15), plasma triglyceride (Chromosomes 5, 7), gallstones (Chromosome 2), and obesity (Chromosomes 4, 6, 7, 9, 12, 15). Authors use Lipc, Brn3.1, Ghrhrr, Gad-1ps, Otf11, Sel1, Tcfcoup2, Crfr, Brn5.0, G6pd, Otf9, Igl1, Pgs1, Lgals1 and Lgals2 for locus symbols Hpl, Pou4f3, Ghrhr, Gad1-ps, Pou2f3, DSell, Aporp1, Crhr, Pou6f1, G6pdx, Pou3f4, Igl-5, Ptgs1, Lgals4 and Lgals6 respectively.

CROSS

• Type
  Backcross, female
• Female Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>/<s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s>
• Strain
  (C57BL/6J x M. spretus)F1
• Male Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>/<b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>
• Strain
  C57BL/6J
• Mapping Panel
  UCLA (BSB)
• Allele 1
  b from C57BL/6J
• Allele 2
  s from M. spretus

2x2 Data Reported

Marker 1	Marker 2	# Recombinants	# Parentals
Apob	D12Ucla8	0	63
Apob	Rrm2	7	59
D12Ucla8	Rrm2	7	59
Rrm2	D12Ucla6	10	56
Rrm2	D12Ucla7	10	56
D12Ucla6	D12Ucla7	0	65
D12Ucla6	D12Mit36	8	57
D12Ucla7	D12Mit36	8	57
D12Mit36	Fdpsl6	2	64
Fdpsl6	Acot1	7	59
Acot1	D12Ucla3	1	64
D12Ucla3	Serpina1b	4	60
Serpina1b	D12Ucla4	1	62
Serpina1b	D12Ucla9	1	62
Serpina1b	Pre2	1	62
Serpina1b	D12Ucla5	1	62
D12Ucla4	D12Ucla9	0	64
D12Ucla4	Pre2	0	64
D12Ucla4	D12Ucla5	0	64
D12Ucla9	Pre2	0	64
D12Ucla9	D12Ucla5	0	64
Pre2	D12Ucla5	0	64
D12Ucla4	D12Mit141	8	57
D12Ucla9	D12Mit141	8	57
Pre2	D12Mit141	8	57
D12Ucla5	D12Mit141	8	57
D12Mit141	D12Nds2	1	44
D12Nds2	Igh	0	45

Statistics

Marker 1	Marker 2	# Recombinants	Total	% Recombinants	Std Error
Apob	D12Ucla8	0	63	0.000	0.000
Apob	Rrm2	7	66	10.606	3.790
D12Ucla8	Rrm2	7	66	10.606	3.790
Rrm2	D12Ucla6	10	66	15.152	4.413
Rrm2	D12Ucla7	10	66	15.152	4.413
D12Ucla6	D12Ucla7	0	65	0.000	0.000
D12Ucla6	D12Mit36	8	65	12.308	4.075
D12Ucla7	D12Mit36	8	65	12.308	4.075
D12Mit36	Fdpsl6	2	66	3.030	2.110
Fdpsl6	Acot1	7	66	10.606	3.790
Acot1	D12Ucla3	1	65	1.538	1.527
D12Ucla3	Serpina1b	4	64	6.250	3.026
Serpina1b	D12Ucla4	1	63	1.587	1.575
Serpina1b	D12Ucla9	1	63	1.587	1.575
Serpina1b	Pre2	1	63	1.587	1.575
Serpina1b	D12Ucla5	1	63	1.587	1.575
D12Ucla4	D12Ucla9	0	64	0.000	0.000
D12Ucla4	Pre2	0	64	0.000	0.000
D12Ucla4	D12Ucla5	0	64	0.000	0.000
D12Ucla9	Pre2	0	64	0.000	0.000
D12Ucla9	D12Ucla5	0	64	0.000	0.000
Pre2	D12Ucla5	0	64	0.000	0.000
D12Ucla4	D12Mit141	8	65	12.308	4.075
D12Ucla9	D12Mit141	8	65	12.308	4.075
Pre2	D12Mit141	8	65	12.308	4.075
D12Ucla5	D12Mit141	8	65	12.308	4.075
D12Mit141	D12Nds2	1	45	2.222	2.197
D12Nds2	Igh	0	45	0.000	0.000