Mapping Data

Experiment

• Experiment
  CROSS
• Chromosome
  13
• Reference
  J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
• ID
  MGI:48090

Genes

Gene	Assay Type	Description
D13Mit3	PCR amplified length variant
D13Mit17	PCR amplified length variant
D13Ucla6	reported elsewhere
Fdpsl7	reported elsewhere
D13Ucla3	reported elsewhere
D13Ucla4	reported elsewhere
D13Mit7	PCR amplified length variant
Dapk1	reported elsewhere
Pou5f2	reported elsewhere
Hmgcr	reported elsewhere
D13Ucla5	reported elsewhere
Bhmt2	reported elsewhere
Hmgcs1	Southern analysis	p35K-312
D13Mit32	PCR amplified length variant

Notes

• Reference
  The marker maps experimentally derived in this paper were overlapped with published maps for a number of QTL regions associated with plasma total cholesterol (Chromosomes 1, 5, 6, 7, 12, 15 ,18), plasma HDL cholesterol (Chromosomes 1, 5, 7, 17), plasma LDL/VLDL cholesterol (Chromosomes 9, 12, 13, 15), plasma triglyceride (Chromosomes 5, 7), gallstones (Chromosome 2), and obesity (Chromosomes 4, 6, 7, 9, 12, 15). Authors use Lipc, Brn3.1, Ghrhrr, Gad-1ps, Otf11, Sel1, Tcfcoup2, Crfr, Brn5.0, G6pd, Otf9, Igl1, Pgs1, Lgals1 and Lgals2 for locus symbols Hpl, Pou4f3, Ghrhr, Gad1-ps, Pou2f3, DSell, Aporp1, Crhr, Pou6f1, G6pdx, Pou3f4, Igl-5, Ptgs1, Lgals4 and Lgals6 respectively.

CROSS

• Type
  Backcross, female
• Female Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>/<s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s>
• Strain
  (C57BL/6J x M. spretus)F1
• Male Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>/<b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>
• Strain
  C57BL/6J
• Mapping Panel
  UCLA (BSB)
• Allele 1
  b from C57BL/6J
• Allele 2
  s from M. spretus

2x2 Data Reported

Marker 1	Marker 2	# Recombinants	# Parentals
D13Mit3	D13Mit17	2	40
D13Mit17	D13Ucla6	8	37
D13Ucla6	Fdpsl7	6	54
Fdpsl7	D13Ucla3	1	62
D13Ucla3	D13Ucla4	7	59
D13Ucla4	D13Mit7	2	63
D13Ucla4	Dapk1	2	63
D13Mit7	Dapk1	0	65
D13Mit7	Pou5f2	5	60
Dapk1	Pou5f2	5	60
Pou5f2	Hmgcr	3	62
Pou5f2	D13Ucla5	3	62
Pou5f2	Bhmt2	3	62
Hmgcr	Hmgcs1	10	56
D13Ucla5	Hmgcs1	10	56
Bhmt2	Hmgcs1	10	56
Hmgcs1	D13Mit32	3	63

Statistics

Marker 1	Marker 2	# Recombinants	Total	% Recombinants	Std Error
D13Mit3	D13Mit17	2	42	4.762	3.286
D13Mit17	D13Ucla6	8	45	17.778	5.699
D13Ucla6	Fdpsl7	6	60	10.000	3.873
Fdpsl7	D13Ucla3	1	63	1.587	1.575
D13Ucla3	D13Ucla4	7	66	10.606	3.790
D13Ucla4	D13Mit7	2	65	3.077	2.142
D13Ucla4	Dapk1	2	65	3.077	2.142
D13Mit7	Dapk1	0	65	0.000	0.000
D13Mit7	Pou5f2	5	65	7.692	3.305
Dapk1	Pou5f2	5	65	7.692	3.305
Pou5f2	Hmgcr	3	65	4.615	2.602
Pou5f2	D13Ucla5	3	65	4.615	2.602
Pou5f2	Bhmt2	3	65	4.615	2.602
Hmgcr	Hmgcs1	10	66	15.152	4.413
D13Ucla5	Hmgcs1	10	66	15.152	4.413
Bhmt2	Hmgcs1	10	66	15.152	4.413
Hmgcs1	D13Mit32	3	66	4.545	2.564