Mapping Data

Experiment

• Experiment
  CROSS
• Chromosome
  14
• Reference
  J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
• ID
  MGI:48091

Genes

Gene	Assay Type	Description
D14Ucla4	reported elsewhere
Fdft1	Southern analysis	pRSS1327
D14Mit2	PCR amplified length variant
Dcaf11	reported elsewhere
Dhrs4	reported elsewhere
Clu	reported elsewhere
D14Mit42	PCR amplified length variant

Notes

• Reference
  The marker maps experimentally derived in this paper were overlapped with published maps for a number of QTL regions associated with plasma total cholesterol (Chromosomes 1, 5, 6, 7, 12, 15 ,18), plasma HDL cholesterol (Chromosomes 1, 5, 7, 17), plasma LDL/VLDL cholesterol (Chromosomes 9, 12, 13, 15), plasma triglyceride (Chromosomes 5, 7), gallstones (Chromosome 2), and obesity (Chromosomes 4, 6, 7, 9, 12, 15). Authors use Lipc, Brn3.1, Ghrhrr, Gad-1ps, Otf11, Sel1, Tcfcoup2, Crfr, Brn5.0, G6pd, Otf9, Igl1, Pgs1, Lgals1 and Lgals2 for locus symbols Hpl, Pou4f3, Ghrhr, Gad1-ps, Pou2f3, DSell, Aporp1, Crhr, Pou6f1, G6pdx, Pou3f4, Igl-5, Ptgs1, Lgals4 and Lgals6 respectively.

CROSS

• Type
  Backcross, female
• Female Parent
  <b> <b> <b> <b> <b> <b> <b>/<s> <s> <s> <s> <s> <s> <s>
• Strain
  (C57BL/6J x M. spretus)F1
• Male Parent
  <b> <b> <b> <b> <b> <b> <b>/<b> <b> <b> <b> <b> <b> <b>
• Strain
  C57BL/6J
• Mapping Panel
  UCLA (BSB)
• Allele 1
  b from C57BL/6J
• Allele 2
  s from M. spretus

2x2 Data Reported

Marker 1	Marker 2	# Recombinants	# Parentals
D14Ucla4	Fdft1	2	61
Fdft1	D14Mit2	3	60
D14Mit2	Dcaf11	15	46
Dcaf11	Dhrs4	1	60
Dhrs4	Clu	4	62
Clu	D14Mit42	14	49

Statistics

Marker 1	Marker 2	# Recombinants	Total	% Recombinants	Std Error
D14Ucla4	Fdft1	2	63	3.175	2.209
Fdft1	D14Mit2	3	63	4.762	2.683
D14Mit2	Dcaf11	15	61	24.590	5.514
Dcaf11	Dhrs4	1	61	1.639	1.626
Dhrs4	Clu	4	66	6.061	2.937
Clu	D14Mit42	14	63	22.222	5.238