Mapping Data

Experiment

• Experiment
  CROSS
• Chromosome
  7
• Reference
  J:34178 Welch CL, et al., Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. J Lipid Res. 1996 Jul;37(7):1406-21
• ID
  MGI:48100

Genes

Gene	Assay Type	Description
Lgals4	reported elsewhere
Lgals6	reported elsewhere
D7Ucla5	reported elsewhere
Apoe	reported elsewhere
Lipe	reported elsewhere
D7Ucla2	reported elsewhere
D7Mit20	PCR amplified length variant
D7Mit52	PCR amplified length variant
Nr2f2	Southern analysis	Arp-1 CoZFrag
D7Mit17	PCR amplified length variant
D7Ucla6	reported elsewhere
D7Ucla7	reported elsewhere
D7Mit7	PCR amplified length variant
D7Mit8	PCR amplified length variant
D7Mit187	PCR amplified length variant
D7Ucla1	reported elsewhere
D7Mit12	PCR amplified length variant
D7Nds4	reported elsewhere

Notes

• Reference
  The marker maps experimentally derived in this paper were overlapped with published maps for a number of QTL regions associated with plasma total cholesterol (Chromosomes 1, 5, 6, 7, 12, 15 ,18), plasma HDL cholesterol (Chromosomes 1, 5, 7, 17), plasma LDL/VLDL cholesterol (Chromosomes 9, 12, 13, 15), plasma triglyceride (Chromosomes 5, 7), gallstones (Chromosome 2), and obesity (Chromosomes 4, 6, 7, 9, 12, 15). Authors use Lipc, Brn3.1, Ghrhrr, Gad-1ps, Otf11, Sel1, Tcfcoup2, Crfr, Brn5.0, G6pd, Otf9, Igl1, Pgs1, Lgals1 and Lgals2 for locus symbols Hpl, Pou4f3, Ghrhr, Gad1-ps, Pou2f3, DSell, Aporp1, Crhr, Pou6f1, G6pdx, Pou3f4, Igl-5, Ptgs1, Lgals4 and Lgals6 respectively.

CROSS

• Type
  Backcross, female
• Female Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>/<s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s> <s>
• Strain
  (C57BL/6J x M. spretus)F1
• Male Parent
  <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>/<b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b> <b>
• Strain
  C57BL/6J
• Mapping Panel
  UCLA (BSB)
• Allele 1
  b from C57BL/6J
• Allele 2
  s from M. spretus

2x2 Data Reported

Marker 1	Marker 2	# Recombinants	# Parentals
Lgals4	Lgals6	0	66
Lgals4	D7Ucla5	0	66
Lgals6	D7Ucla5	0	66
Lgals4	Apoe	3	63
Lgals6	Apoe	3	63
D7Ucla5	Apoe	3	63
Apoe	Lipe	1	65
Apoe	D7Ucla2	1	65
Apoe	D7Mit20	1	65
Lipe	D7Ucla2	0	66
D7Ucla2	D7Mit20	0	63
Lipe	D7Mit52	6	57
D7Ucla2	D7Mit52	6	57
D7Mit20	D7Mit52	6	57
D7Mit52	Nr2f2	3	53
Nr2f2	D7Mit17	9	41
Nr2f2	D7Ucla6	9	41
D7Mit17	D7Ucla6	0	50
D7Mit17	D7Ucla7	4	62
D7Ucla6	D7Ucla7	4	62
D7Ucla7	D7Mit7	5	48
D7Mit7	D7Mit8	1	35
D7Mit8	D7Mit187	3	38
D7Mit187	D7Ucla1	1	59
D7Ucla1	D7Mit12	5	57
D7Mit12	D7Nds4	2	61

Statistics

Marker 1	Marker 2	# Recombinants	Total	% Recombinants	Std Error
Lgals4	Lgals6	0	66	0.000	0.000
Lgals4	D7Ucla5	0	66	0.000	0.000
Lgals6	D7Ucla5	0	66	0.000	0.000
Lgals4	Apoe	3	66	4.545	2.564
Lgals6	Apoe	3	66	4.545	2.564
D7Ucla5	Apoe	3	66	4.545	2.564
Apoe	Lipe	1	66	1.515	1.504
Apoe	D7Ucla2	1	66	1.515	1.504
Apoe	D7Mit20	1	66	1.515	1.504
Lipe	D7Ucla2	0	66	0.000	0.000
D7Ucla2	D7Mit20	0	63	0.000	0.000
Lipe	D7Mit52	6	63	9.524	3.698
D7Ucla2	D7Mit52	6	63	9.524	3.698
D7Mit20	D7Mit52	6	63	9.524	3.698
D7Mit52	Nr2f2	3	56	5.357	3.009
Nr2f2	D7Mit17	9	50	18.000	5.433
Nr2f2	D7Ucla6	9	50	18.000	5.433
D7Mit17	D7Ucla6	0	50	0.000	0.000
D7Mit17	D7Ucla7	4	66	6.061	2.937
D7Ucla6	D7Ucla7	4	66	6.061	2.937
D7Ucla7	D7Mit7	5	53	9.434	4.015
D7Mit7	D7Mit8	1	36	2.778	2.739
D7Mit8	D7Mit187	3	41	7.317	4.067
D7Mit187	D7Ucla1	1	60	1.667	1.653
D7Ucla1	D7Mit12	5	62	8.065	3.458
D7Mit12	D7Nds4	2	63	3.175	2.209