Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  8
• Reference
  J:162530 White RA, et al., Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan). Blood Cells Mol Dis. 2009 Sep-Oct;43(2):141-8
• ID
  MGI:4820802

Genes

Gene	Description
Klf1	osmotic fragility and elevated zinc protoporphyrin.
Hook2
Trir
Zfp791
Mylk3
D8Mit327
Dand5

Notes

• Experiment
  The Nan mutation was originally generated by N-ethyl-N-nitrosurea
  (enu) mutagenesis on the C3H strain. The Nan mutation was then transferred to C57BL/6J (B6) and WB/ReJ. For mapping Nan WB-Nan/+ mice were crossed with MOLD/Rk and SWR/J mice. WBMOLDF1-Nan/+and WBSWRF1-Nan/+ F1
  Mice were subsequently backcrossed to WB-+/+ mice resulting in 1238 and 897
  Backcross mice respectively. The 2135 backcross progeny were used to map the Nan locus to mouse Chromosome 8. The Nan mice were scored by the presence ofosmotic fragility and elevated zinc protoporphyrin.
  
  
  
  Nan did not recombine with markers Hook2, 2310036O22Rik, Zfp791 and Mylk3. The Authors indicated that the critical region for Nan was defined by markers Dand5, at
  0.08 cM on the proximal side with 1crossover, and D8Mit327, at 0.16 cM on the distal side with 2 crossovers. Nan spans a region of 648 Kb. The 648 Kb sequence is represented in GenBank contig NT078575