Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  6
• Reference
  J:36727 Zenklusen JC, et al., Novel susceptibility locus for mouse hepatomas: evidence for a conserved tumor suppressor gene. Genome Res. 1996 Nov;6(11):1070-6
• ID
  MGI:48235

Genes

Gene	Assay Type	Description
D6Mit179	PCR amplified length variant
Tsp8	visible phenotype	LOH
D6Mit50	PCR amplified length variant

Notes

• Experiment
  LOH (loss of heterozygosity) in hepatic adenomas obtained from C57BL/6N x C3H/HeN mice indicated that the mouse homologue, Tsp8, of the human 7q31 locus ST7-LSB was conserved in mouse. Microsatellite markers polymorphic between mouse strains C57BL/6N andC3H/HeN were informative to show that a region of 0.2 cM in band A2 of mouse Chromosome 6 between markers D6Mit50 and D6Mit179 exhibited the most frequent LOH. Significantly, from a total of 112 tumors, 90.7% showed an LOH at the D6Mit50 marker and 89.5% showed an LOH at the D6Mit179 marker.