Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  18
• Reference
  J:39174 Smits R, et al., Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis. Carcinogenesis. 1997 Feb;18(2):321-7
• ID
  MGI:48448

Genes

Gene	Assay Type	Description
Apc	PCR amplified length variant	Apc-A2/Apc-C2, Apc-A2/Neo3
D18Mit35	PCR amplified length variant
D18Mit81	PCR amplified length variant
D18Mit80	PCR amplified length variant

Notes

• Experiment
  Authors tested 22 (C3H x C57BL/6)F1-Apc⁺/Apc^1638N tumors for the presence of LOH at Apc, D18Mit35, D18Mit81 and D18Mit80 on mouse Chromosome 18. Of the 14 tumors where the Apc gene was found to be lost, 13 showed LOH at all of the Chromosome 18 markers tested and 1 did not show any loss of the markers tested. This data shows that mouse Chromosome 18 is involved in the loss of the wildtype Apc allele.