Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  9
• Reference
  J:30526 Pearce RB, et al., Association of an androgen-responsive T cell phenotype with murine diabetes and Idd2. Autoimmunity. 1995;20(4):247-58
• ID
  MGI:48487

Genes

Gene	Assay Type
D9Mit12	PCR amplified length variant
Idd2	visible phenotype
Tlf	visible phenotype

Notes

• Experiment
  The percentage of circulating CD4+ T Cells in NOD/Smrf mice is 40-50% greater then NON/Lt mice, enabling the investigation of how this quantitative phenotype segregates in a BC1 population (NON/Lt x NOD/Smrf)F1 x NOD/Smrf and in an F2 population (NON/Lt x NOD/Smrf)F1 x (NON/Lt x NOD/Smrf)F1. Statistical analysis using t-tests showed a significant correlation of circulating CD4+ T cells with the mouse Chromosome 9 marker D9Mit12 in both male and female segregants. The gene or genetic region responsible for this phenotype is termed Tlf (T lymphocyte frequency) Importantly, the authors show a correlation of Tlf with diabetic incidence as expressed by NON/Lt and NOD/Smrf mice suggesting that Tlf may in fact be the mouse Chromosome 9 locus Idd2.