Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  13
• Reference
  J:170533 Lawson HA, et al., The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J x SM/J murine model. Mamm Genome. 2011 Apr;22(3-4):197-208
• ID
  MGI:4948141

Genes

Gene
Ddiab42
Ddiab43
Ddiab44
Ddiab45
Ddiab46
Ddiab47
Ddiab48
Ddiab49

Notes

• Experiment
  The mice used in this study were from the F16 generation of
  the LG/J X SM/J Advanced Intercross Line (Wustl:LG,SM-G16).
  
  The authors indicated 70 trait-specific QTL mapping to 64 locations,
  and of these 70 a total of 17 are significant at the genome-wide level. Fifty three are significant at the chromosome level.
  
  The 17 genome wide significant QTL are indicated with an '*' and can be viewed here on their respective chromosome mapping records (NCBI37/mm9).
  
  The authors mentioned that phenotypic variation in response to glucosestresswas indicated by using an intraperitoneal injection of 0.01 ml of 10% glucose solution per
  gram of body weight. The measurements taken over the course of 2 hours were used to calculate the area under the curve (AUC), which was used as overall measure of glucose tolerance.
  
  Phenotypes were as follows:
  AUC_10wks indicates under the curve at 10 weeks
  AUC_20wks indicates area under the curve at 20 weeks
  bGLC_10wks indicates basal glucose level at 10 weeks
  bGLC_20wks indicates basal glucose level at 20 weeks,
  GLC indicates serum glucose level at necropsy
  INS indicates serum insulin level at necropsy
  
  
  Chr MGI Author Pheno LOD Peak Mb 5 prime 3 Prime
  
  13 Ddiab42 Ddiab13a AUC_20wks 3.06 29.67 21.92 33.36
  13 Ddiab43 Ddiab13b bGLC_10wks 2.7 40.51 39.41 41.83
  13 Ddiab44 Ddiab13c bGLC_10wks 2.73 61.03 57.9 62.99
  13 *Ddiab45 Ddiab13d INS 4.56 68.92 67.81 73.33
  13 Ddiab46 Ddiab13e AUC_20wks 3.24 87.1 86.46 88.39
  13 Ddiab47 Ddiab13f AUC_20wks 3.83 96.15 93.17 97.71
  13 Ddiab48 Ddiab13g bGLC_10wks 3.07 105.42 104.62 107.09
  13 *Ddiab49 Ddiab13h AUC_10wks 4.75 114.7 112.87 119.12
  13 Ddiab49 Ddiab13h AUC_20wks 2.91 116.61